A Ten-Year Review of Ovarian Cancer in Enugu, South East Nigeria

CA Iyoke, CO Ifeadike, CC Nnebue, PO Nkwo, EC Ezugwu, L Edosuyi, LN Onah, HE Onah, O Okafor

Abstract


Objective: To review the pattern and management of
ovarian cancer over a ten-year period at the University of
Nigeria Teaching Hospital, Enugu.
Methods: A retrospective review of cases of histologically
diagnosed primary ovarian cancers from January 1, 2000 to
December 31, 2009.
Results: Out of 20,227 gynaecological admissions during
the study period, 200 cases of primary gynaecological
cancers were involved. Ovarian cancer constituted 25.0% of
all gynaecological malignancies giving an incidence rate of 1
per 405 gynaecological admissions per year. The mean age
of cases at presentation was 45.4 ± 17.1years. Epithelial
ovarian cancer constituted 68.0% of ovarian cancer.
Approximately 60.0% of women who had epithelial ovarian
cancer were aged 50 years or below. Parous women
constituted 72.4% of epithelial ovarian cancer out of which
38.0% were grandmultiparous women. All the cancers in
pre-menarcheal girls were germ cell tumours. Most of the
cases had surgery and adjuvant chemotherapy. However,

most patients (68.0%) had only one or two courses of cisplatinum
based combination chemotherapy only to
abandon further treatment.
Conclusion: This study supports an emerging pattern of
early onset of, and substantial involvement of multiparous
women in, epithelial ovarian cancer among patients treated
at the study centre. The management challenge posed by
the pattern of presentation of a majority of cases is
compounded by a trend towards abandonment of
chemotherapy by most patients.


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