HIV/TB Co-infection Among HIV Positive Children Attending Clinics In Imo State University Teaching Hospital Orlu, Imo State, Nigeria

CB Duru, KA Uwakwe, KC Diwe, CC Nnebue

Abstract


Background: Human Immunodeficiency Syndrome and
tuberculosis are among the leading causes of death from
infectious diseases worldwide. The resurgence of
tuberculosis in children is partly attributed to the coexisting
burden of human immunodeficiency virus
infection, which is most pronounced in sub Saharan Africa.
Aim: To determine the prevalence and pattern of HIV/TB
co-infection among HIV positive children attending clinics
at Imo State University Teaching Hospital.
Method: This is a retrospective review of HIV/AIDS
children attending HIV clinics at Imo State University
Teaching Hospital, Orlu, Imo State, Nigeria from January,
2011- December, 2012.
Results: Of the total of 128 HIV infected children
reviewed during the 24 months period, 16(12.5%) were coinfected
with tuberculosis, (95% CI, 10.7% - 14.3%). Among
these 16 patients, TB co-infection was diagnosed before
commencement of ART in 93.7% of them. Majority of the
TB cases (87.5%) presented with pulmonary TB amongst
whom only 25.0% were sputum positive. The factors found
to affect TB development significantly were stage of HIV
disease (p=0.000) and CD4 count level (P=0.021) of
patients. The factor with the highest influence on TB
development was the clinical stage of HIV disease (Odds ratio =6.013) and that of least influence was sex of patient(Odds ratio= 0.8319).

Conclusion: The study revealed a moderately high
TB/HIV co-infection rate. Low CD4 count level below
200cell/ml and late clinical stages of HIV disease
contribute significantly to the development of TB disease


Full Text:

PDF

Refbacks

  • There are currently no refbacks.